Assessment of alveolar bone changes in response to minimally invasive periodontal surgery: A cone-beam computed tomographic evaluation.

Purpose: The aim of this study was to evaluate 3-dimensional cone-beam computed tomography (CBCT) images of alveolar bone changes in patients who underwent minimally invasive periodontal surgery-namely, the pinhole surgical technique (PST). Materials and Methods: Alveolar bone height was measured and compared on CBCT images of 254 teeth from 23 consecutive patients with Miller class I, II, or III recession who had undergone PST. No patient with active periodontal disease was selected for surgery. Two different methods were used to assess the alveolar bone changes postoperatively. In both methods, the distance between the apex of the tooth and the mid-buccal alveolar crestal bone on pre- and post-surgical CBCT studies was measured. Results: An average alveolar bone gain >0.5 mm following PST was identified using CBCT (P=0.05). None of the demographic variables, including sex, age, and time since surgery, had any significant effect on bone gain during follow-up, which ranged from 8 months to 3 years. Conclusion: PST appears to be a promising treatment modality for recession that results in stable clinical outcomes and may lead to some level of resolution on the bone level. More long-term studies must be done to evaluate the impact of this novel technique on bone remodeling and to assess sustained bone levels within a larger study population.

Effect of a Motion Artifact Correction System on Cone-Beam Computed Tomography Image Characteristics.

OBJECTIVES: Determine the effect of the motion correction system on cone-beam computed tomography (CBCT) image quality parameters, artifacts, and contrast-to-noise ratio (CNR) using different motion settings. MATERIALS AND METHODS: A customized phantom insert array was prepared using SEDENTEX CT IQ Phantom (Leeds Test Objects, Yorkshire, England) stabilized over a rotating electric turntable. Thirty baseline CBCT scans were acquired with standardized technique factors on the ProMax 3D (Planmeca, Helsinki, Finland) machine using combinations of different motion settings, including no motion, three- and six-degree motion, and with and without the use of a motion correction system. The standardized images were exported to ImageJ software. Image quality parameters, artifacts, and CNR values were evaluated and compared among the different acquisition settings. RESULTS: The use of the motion correction system algorithm compared with the different motion settings showed a statistically significant difference for all the parameters (p<0.05) except for artifact values for six-degree motion (p<0.07). The effect of different motion settings on the parameters was not statistically significant. CONCLUSION: The use of a motion correction system, a proprietary algorithm-based system incorporated in the ProMax 3D CBCT unit, deteriorates the image quality characteristics evaluated in this in vitro study, namely artifact value and CNR. Its use in clinical settings might be limited to situations where patient motion is expected and appropriate head stabilization is not possible due to age or disease.

Review of Immune-Related Adverse Events (irAEs) in Non-Small-Cell Lung Cancer (NSCLC)-Their Incidence, Management, Multiorgan irAEs, and Rechallenge.

Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced malignancies, including non-small cell lung cancer (NSCLC). These agents have improved clinical outcomes and have become quite an attractive alternative alone or combined with other treatments. Although ICIs are tolerated better, they also lead to unique toxicities, termed immune-related adverse events (irAEs). A reconstituted immune system may lead to dysregulation in normal immune self-tolerance and cause inflammatory side effects (irAEs). Although any organ system can be affected, immune-related adverse events most commonly involve the gastrointestinal tract, endocrine glands, skin, and liver. They can occur anytime during the treatment course and rarely even after completion. Owen and colleagues showed that approximately 30% of patients with NSCLC treated with ICIs develop irAEs. Kichenadasse et al. conducted a thorough evaluation of multiorgan irAEs, which is of particular interest because information regarding these types of irAEs is currently sparse. It is important to delineate between infectious etiologies and symptom progression during the management of irAEs. Close consultation with disease-specific subspecialties is encouraged. Corticosteroids are the mainstay of treatment of most irAEs. Early intervention with corticosteroids is crucial in the general management of immune-mediated toxicity. Grade 1-2 irAEs can be closely monitored; hypothyroidism and other endocrine irAEs may be treated with hormone supplementation without the need for corticosteroid therapy. Moderate- to high-dose steroids and other additional immunosuppressants such as tocilizumab and cyclophosphamide might be required in severe, grade 3-4 cases. Recently, increasing research on irAEs after immunotherapy rechallenge has garnered much attention. Dolladille and colleagues assessed the safety in patients with cancer who resumed therapy with the same ICIs and found that rechallenge was associated with about 25-30% of the same irAEs experienced previously (4). However, such data should be carefully considered. Further pooled analyses may be required before we conclude about ICIs' safety in rechallenge.

Trends in oral and maxillofacial radiology career: A survey.

PURPOSE/OBJECTIVES: To understand the professional aspirations of oral and maxillofacial radiologists (OMRs) by exploring their career choices and their association with educational background, engagement in professional activities, professional values, and overall level of career satisfaction. METHODS: This prospective cross-sectional study surveyed board-certified OMRs in the United States and Canada from September to December 2019. A web-based questionnaire was created comprising 37 multiple-choice questions and an open-ended question focusing on their opinions regarding the profession's future. A thematic approach qualitatively explored open questions. RESULTS: Of the 86 OMRs, 68, 10, and eight were board certified in the United States, Canada, and both countries, respectively. Activities considered "rewarding" included teaching and mentoring (65%) and radiologic reporting (55%). The majority spent approximately 20-30 h/week writing radiographic reports and less than 10 h in research. On an average, OMRs produced 21.9 (SD 12.8) reports per day. Activities considered less rewarding included administrative work (11%) and productivity pressure in institutions. OMRs working in academia reported higher incomes (p < 0.05). Finally, the majority of the OMRs were pleased with their career choices (79%). CONCLUSIONS: There is an association between the contemporary OMRs' satisfaction feeling, teaching/mentoring, and the future challenges of participating in multidisciplinary teams. Overall, diverse career choices lead OMRs to be proud of their profession and significantly satisfied.

Comparison of photothermal radiometry and modulated luminescence, intraoral radiography, and cone beam computed tomography for detection of natural caries under restorations.

OBJECTIVES: The aim of this ex vivo study was to measure the sensitivity, specificity, and receiver operating characteristic (ROC) area under the curve (AUC) of a caries diagnostic system based on photothermal radiometry and modulated luminescence (PTR/LUM) and compare them with the values for digital intraoral radiography (IR) and cone beam computed tomography (CBCT) in detecting recurrent decay. STUDY DESIGN: Class 2 composite restorations were prepared on 70 proximal surfaces: 35 with caries and 35 without caries. The gingival floor of the restored surfaces was assessed for caries under the restorations using each of the 3 modalities. Statistical calculations and analysis were performed using the R statistical computing environment. RESULTS: The average scores for sensitivity among the 6 observers were 0.89 for PTR/LUM, 0.38 for IR, and 0.40 for CBCT. Sensitivity for PTR/LUM was significantly greater than sensitivity for IR and CBCT. Average scores for specificity were 0.83, 0.80, and 0.70 for PTR/LUM, IR, and CBCT, respectively. CBCT had significantly lower specificity. The AUC was 0.65 for IR and 0.59 for CBCT, which were significantly different. PTR/LUM had moderate intraobserver agreement. CONCLUSIONS: PTR/LUM, which involves non-ionizing radiation, can serve as a sensitive adjunct in early caries detection and monitoring.

Implementation of a modified quality assurance protocol for CBCT machines within UT health San Antonio School of Dentistry.

OBJECTIVES: To implement the quality control assurance protocol (including the re-establishment of baseline data from 2016) to monitor the stability of image quality of CBCT machines located within the UT Health San Antonio School of Dentistry. METHODS AND MATERIALS: Five CBCT machines ProMax 3D Mid® (Planmeca Oy, Helsinki, Finland), 3D Accuitomo XYZ Slice View Tomograph® (Model MCT-1, Type EX-1F8; Fushimi-ku, Kyoto: J. Morita Mfg. Corp), Veraviewepocs 3D (Model R100; Fushimi-ku, Kyoto: J. Morita Mfg. Corp), PreXion3D Excelsior® (PreXion, San Mateo, CA), and i-CAT FLX Series® (Imaging Sciences International, Hatfield, PA) were tested for Artifact, Contrast-to-Noise Ratio, Noise, Spatial Resolution, and Contrast Resolution using a custom insert configuration in the SEDENTEXCT IQ phantom. RESULTS: Four-scan benchmark mean values for Artifact, Contrast-to-Noise, Noise, Spatial Resolution, and Contrast Resolution were determined for the five machines tested with associated alert and action level thresholds calculated. CONCLUSION: This newly developed QA protocol established image quality baseline values. Recommended tests, frequency, and actions levels have been updated and control charts established for future trend analysis to enable proper implementation of a QA protocol monitoring CBCT machines at UT health San Antonio.

Evaluation of artifacts generated by titanium, zirconium, and titanium-zirconium alloy dental implants on MRI, CT, and CBCT images: A phantom study.

OBJECTIVE: The aim of this study was to assess artifacts generated by zirconium, titanium, and titanium-zirconium alloy implants on magnetic resonance imaging(MRI), computed tomography(CT), and cone beam computed tomography(CBCT) and to correlate the findings to the dose-area product and exposure factors on CT and CBCT. STUDY DESIGN: Three phantoms were built by embedding zirconium, titanium, and titanium-zirconium implants in ultrasound gel. MRI, CT, and CBCT images were acquired by using multiple sequences and settings. For MRI, "artifact" was described as the length of signal void beyond the limits of the implant. For CT and CBCT, "artifact" was calculated by subtracting the gray level of the darkest pixel from the level of the lightest pixel. RESULTS: On MRI, zirconium implants had minor distortion artifacts, whereas titanium and titanium-zirconium implants created extensive artifacts (P < .05). On CT and CBCT, artifacts were less prominent with titanium and titanium-zirconium implants compared with zirconium (P < .05). Titanium grade 5 implants with 0.3 and 0.4 mm3 voxels produced the least severe artifacts. CONCLUSIONS: MRI images were less affected by artifacts from zirconium implants, whereas CT and CBCT images showed less severe artifacts from titanium and titanium-zirconium alloy implants. CT generated greater artifacts compared with CBCT. Larger CBCT voxel sizes reduced the dose-area product and the severity of artifacts.

3D Volume Rendering and 3D Printing (Additive Manufacturing).

Three-dimensional (3D) volume-rendered images allow 3D insight into the anatomy, facilitating surgical treatment planning and teaching. 3D printing, additive manufacturing, and rapid prototyping techniques are being used with satisfactory accuracy, mostly for diagnosis and surgical planning, followed by direct manufacture of implantable devices. The major limitation is the time and money spent generating 3D objects. Printer type, material, and build thickness are known to influence the accuracy of printed models. In implant dentistry, the use of 3D-printed surgical guides is strongly recommended to facilitate planning and reduce risk of operative complications.

Optical Coherence Tomography.

Optical coherence tomography (OCT) is a noninvasive diagnostic technique providing cross-sectional images of biologic structures based on the differences in tissue optical properties. OCT has been widely used in numerous clinical applications and is becoming popular as a promising technology in dentistry. Today, dental hard (tooth) and soft (hard palate mucosa and gingiva mucosa) tissues are visualized with OCT. With new developments in technology, the applications of OCT are being investigated in various fields in dentistry, such as to detect microleakage around restoration, tooth cracks/fractures, examination of periodontal tissues/pockets, early detection of oral cancerous tissues, and in endodontics for location of pulp canal.

The Therapeutic Potential of Blocking Galectin-3 Expression in Acute Myocardial Infarction and Mitigating Inflammation of Infarct Region: A Clinical Outcome-Based Translational Study.

INTRODUCTION: Increased galectin-3 is associated with ischemic cardiomyopathy, although its role in early remodeling post-myocardial infarction (MI) has not been fully elucidated. There are no data demonstrating that blocking galectin-3 expression would have an impact on the heart and that its relationship to remodeling is not simply an epiphenomenon. The direct association between galectin-3 and myocardial inflammation, dysfunction, and adverse cardiovascular outcomes post-MI was examined using clinical and translational studies. METHODS: We performed expression analysis of 9753 genes in murine model of acute MI. For galectin-3 loss of function studies, homozygous galectin-3 knock-out (KO) mice were subjected to coronary artery ligation procedure to induce acute MI (MI, N = 6; Sham, N = 6). For clinical validation, serum galectin-3 levels were measured in 96 patients with ST-elevation MI. Echocardiographic and angiographic parameters of myocardial dysfunction and 3-month composite outcome including mortality, recurrent MI, stroke, and heart failure hospitalization were measured. RESULTS: In the infarct regions of murine models, galectin-3 was a robustly expressed gene. Elevated galectin-3 expression strongly correlated with macrophage-mediated genes. Galectin-3 KO mice showed reduced myocardial macrophage infiltration after acute MI. Galectin-3 levels were higher in patients with early systolic dysfunction, and predicted 3-month major adverse cardiovascular events (area under the curve [AUC]: 0.917 ± 0.063; P = .001). CONCLUSIONS: Galectin-3 is directly associated with early myocardial inflammation post-MI and may represent a potential target for therapeutic inhibition.

Cone beam computed tomography image optimization to detect root fractures in endodontically treated teeth: an in vitro (phantom) study.

OBJECTIVES: The aim of this study was to evaluate the effect of an optimization filter (OF) and voxel size on the accuracy of root fracture detection. STUDY DESIGN: Half of 40 endodontically treated roots were fractured, and the other half were left intact. All teeth were randomly placed into 5 bovine ribs. Each rib was scanned with the Planmeca ProMax 3-D using 4 different settings: 75 µm and 100 µm voxel size with and without an OF. Five reviewers reported if a fracture was present by using a 5-point scale. Intra-/interobserver agreement, area under the receiver operative characteristic curve, accuracy, sensitivity, and false-positive rates were analyzed. RESULTS: High κ-values indicated strong intra-/interobserver agreement. There was no significant difference in fracture detection between any of the evaluated techniques. CONCLUSIONS: Because of the decreased cost, dose area product, and time required, compared with the other imaging modalities studied, the high-resolution mode (100 µm) without an OF is recommended for root fracture detection in endodontically treated teeth.

Myocardial and Serum Galectin-3 Expression Dynamics Marks Post-Myocardial Infarction Cardiac Remodelling.

BACKGROUND: Acute myocardial infarction (MI) causes significant changes in cardiac morphology and function. Galectin-3 is a novel and potentially therapeutically important mediator of cardiac remodelling. Myocardial and serum galectin-3 expression dynamics in response to the early cardiovascular outcomes after acute MI are not fully elucidated. METHODS: We first performed a comprehensive longitudinal microarray analyses in mice after acute MI. We then measured the serum levels of galectin-3 in a translational porcine model of coronary microembolism-induced post-ischaemic cardiac remodelling. We validated our pre-clinical studies in humans by measuring serum galectin-3 levels of 52 patients with acute ST-elevation MI (STEMI) and 11 healthy controls. We analysed galectin-3 data in relation to the development of major adverse cardiovascular outcomes (MACO). RESULTS: Of the 9,753 genes profiled at infarcted and remote myocardium at eight different time points, dynamic myocardial overexpression of galectin-3 mRNA was detected. In a pig model of diffuse myocardial damage and cardiac remodelling, galectin-3 localised to the areas of tissue damage and myocardial fibrosis, with proportionate increase of their serum galectin-3 expression levels. In humans, increased serum galectin-3 level was associated with in-hospital MACO. CONCLUSIONS: In this translational study, we demonstrated that galectin-3 is dynamically overexpressed in response to acute MI-induced cardiac remodelling. Elevated galectin-3 levels are associated with the development of in-hospital MACO.

The effect of milliamperage, number of basis images, and export slice thickness on contrast-to-noise ratio and detection of mandibular canal on cone beam computed tomography scans: an in vitro study.

OBJECTIVES: The aim of this study was to evaluate the effect of milliamperage, number of basis images, and export slice thickness on contrast-to-noise ratio (CNR) and confidence in detecting mandibular canal. STUDY DESIGN: Two phantoms were used. Each phantom consisted of a dry mandible with an epoxy resin bone tissue substitute block and a water-equivalent block, submerged in water. Each mandible was scanned with a Morita 3D Accuitomo cone beam computed tomography (CBCT) machine (Morita, Kyoto, Japan). Scans were made with 180-degree and 360-degree rotations, at 4, 6, and 8 mA. Each scan was exported in Digital Imaging and Communications in Medicine (DICOM) format at slice thicknesses of 0.125 mm, 0.25 mm, 0.75 mm, and 1.0 mm, resulting in 24 image sets for each phantom. The CNR was calculated. Variables were analyzed using factorial analysis of variance. The scans were also evaluated by five observers who were asked to state their confidence in detecting the mandibular canal on a four-point confidence scale. RESULTS: Increasing the number of basis images, milliamperage, or export slice thickness significantly increased the CNR. Reducing the export slice thickness improved observers' confidence in detecting the mandibular canal. CONCLUSIONS: The CBCT acquisition settings should be carefully chosen, depending on specific diagnostic tasks. The lowest slice thickness equal to the voxel size should always be used for exporting CBCT data despite the higher noise.

Incidental findings of skull-base abnormalities in cone-beam computed tomography scans with consultation by maxillofacial radiologists.

INTRODUCTION: Cone-beam computed tomography (CBCT) gives orthodontists and other dental clinicians 3-dimensional information for planning treatment in the craniofacial region. Often overlooked are incidental findings outside the treatment region of interest. METHODS: Two patients with incidental findings of skull-base abnormalities are presented. The orthodontic patient was tentatively diagnosed with a notochordal remnant in the clivus; the implant patient exhibited an empty sella turcica. RESULTS: For the clivus lesion in the orthodontic patient, an artifact was ruled out after a second CBCT image and further distinguished from a fat-containing tumor after magnetic resonance imaging. The impression after magnetic resonance imaging was a notochordal remnant, although chordoma was also included in the differential, warranting a 6-month follow-up magnetic resonance image to confirm the diagnosis. The CBCT study for the implant patient demonstrated an enlarged sella turcica. The impression after the magnetic resonance imaging was an enlarged and partially empty sella with no evidence of a pituitary mass. CONCLUSIONS: Orthodontists and implant surgeons may come across incidental findings outside their area of expertise on CBCT scans, highlighting the importance of appropriate consultation with maxillofacial radiologists. Notochordal remnants may present as nonexpansile intraosseous low-density areas. The challenge in distinguishing these lesions radiographically with chordomas warrants follow-up to confirm a diagnosis. An empty sella is a noteworthy finding because of its potential for endocrine and neuro-ophthalmological disorders despite an asymptomatic presentation.

Arrested Pneumatization of the Sphenoid Sinus on Large Field-of-View Cone Beam Computed Tomography Studies.

Arrested pneumatization of the sphenoid sinus is a normal anatomical variant. The aim of this report is to define cone beam computed tomography (CBCT) characteristics of arrested pneumatization of sphenoid sinus in an effort to help differentiate it from invasive or lytic skull base lesions. Two cases are presented with incidental findings. Both studies, acquired for other diagnostic purposes, demonstrated unique osseous patterns that were eventually deemed to be anatomic variations in the absence of clinical signs and symptoms although the pattern of bone loss and remodeling was diagnosed as pneumatization of the sphenoid sinus by a panel of medical and maxillofacial radiologists following contrasted advanced imaging. It is important to differentiate arrested pneumatization of the sphenoid sinus from lesions, such as arachnoid granulations, acoustic neuroma, glioma, metastatic lesions, meningioma, or chordoma, to prevent unnecessary biopsies or exploratory surgeries that would consequently reduce treatment costs and alleviate anxiety in patients.

Multiple myeloma in bisphosphonate-affected jaws--a diagnostic challenge: case report.

OBJECTIVE: To discuss the challenges in diagnosis and appropriate management of critical underlying pathoses if a patient presents with signs and symptoms indicative of different conditions that may coexist. SUMMARY: This case features clinical and radiographic challenges in reaching a diagnosis in a middle- aged man undergoing bisphosphonate therapy for multiple myeloma. The patient had history of bisphosphonaterelated osteonecrosis of the jaw (BRONJ) in the mandible. The patient presented with pain and swelling in the anterior maxilla, associated with paresthesia of upper lip. The radiographic features were suggestive of BRONJ and invasive fungal sinusitis. MRI appearance was suggestive of malignant involvement by plasmacytoma or lymphoma. Although biopsy is usually not advocated in bisphosphonate-affected jaws, it was advised in this case and was positive for multiple myeloma. Vigilance is required to correlate clinical and radiologic findings and further investigations must be considered if malignancy is suspected.

Configuration of the inferior alveolar canal as detected by cone beam computed tomography.

AIMS: The aim of this study is to evaluate the course of the inferior alveolar canal (IAC) including its frequently seen variations in relation to root apices and the cortices of the mandible at fixed pre-determined anatomic reference points using cone beam volumetric computed tomography (CBVCT). MATERIAL AND METHODS: This retrospective study utilized CBVCT images from 44 patients to obtain quantifiable data to localize the IAC. Measurements to the IAC were made from the buccal and lingual cortical plates (BCP/LCP), inferior border of the mandible and the root apices of the mandibular posterior teeth and canine. Descriptive analysis was used to map out the course of the IAC. RESULTS: IACs were noted to course superiorly toward the root apices from the second molar to the first premolar and closer to the buccal cortical plate anteriorly. The canal was closest to the LCP at the level of the second molar. In 32.95% of the cases, the canal was seen at the level of the canine. CONCLUSIONS: This study indicates that caution needs to be exercised during endodontic surgical procedures in the mandible even at the level of the canine. CBVCT seems to provide an optimal, low-dose, 3D imaging modality to help address the complexities in canal configuration.